Manufacturing News / YMC America, Inc.

Hydrophobic Interaction Chromatography (HIC) Column for Monoclonal Antibodies

Via: ReleaseWire

Updated 8:30 AM CDT, Mon, July 29,2019

Allentown, PA -- (SBWIRE) -- 07/29/2019 -- HIC is often useful for antibody separations because the conditions are non-denaturing, and changes of protein surface-associated hydrophobicity offer high selectivity.

YMC BioPro HIC BF is a hydrophobic interaction chromatography (HIC) column utilizing a butyl (C4) stationary phase bonded to non-porous hydrophilic polymer (methacrylate) particles.

This HIC phase is specifically designed for fast, high resolution separations of proteins and biopharmaceutical drugs such as monoclonal antibodies (mAbs), including drug-to-antibody ratio (DAR) analysis of antibody drug conjugates (ADCs).

YMC BioPro HIC BF has been used with successful results on several commercially available mAb drugs with a run time of under 15 minutes.

The high resolution and good peak shape offered by YMC's BioPro HIC BF material enables detection of small impurities that could be missed when using other phases. Additionally, the use of isopropanol as a modifier helps reduce the retention times of highly-hydrophobic compounds, and is useful for adjusting selectivity and achieving higher recovery.

Read more about YMC BioPro HIC BF at: and contact the company via email at or call 888-341-8380.

About YMC America, Inc.
Established in 1980, YMC America, Inc. is worldwide full-service liquid chromatography company, which offers sales, technical product support, service, application assistance, purification services, contract synthesis and method development.

All YMC products are available worldwide through YMC's network of subsidiaries. This worldwide presence as a full-range chromatography supplier ensures that all YMC products are fully available and fully supported both locally and globally.


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