Manufacturing News / YMC America, Inc.

New Size Exclusion Chromatography Column for Monoclonal Antibodies

Via: ReleaseWire

Updated 11:29 AM CDT, Wed, June 05,2019

Allentown, PA -- (SBWIRE) -- 06/05/2019 -- YMC's newest size exclusion (SEC) column uses a stationary phase specifically designed for separating monoclonal antibodies (mAb). The product, YMC-SEC MAB, utilizes a 3µm, 250Å dihydroxypropyl stationary phase bonded to a silica gel base.

The 250Å pore size of YMC-SEC MAB is well-suited for separating aggregates from monomer and is also effective at resolving lower molecular weight fragments. YMC-SEC MAB delivers high resolution and excellent peak shape over a broad range of molecular weights (10kDa to 700kDa).

YMC-SEC MAB has been shown to work well for both characterization and quality control of antibody drugs.

Key product specifications:
Base particle: 3µm silica
Pore size: 250Å
Functional group: Dihydroxypropyl (Diol)
pH range: 5.0-7.5
Max temperature: 40 °C
Molecular weight: ranges from 10kDa to 700kDa

Benefits of YMC-SEC MAB

Excellent lot-to-lot reproducibility: Virtually no lot-to-lot variability, providing excellent reproducibility for effective quality control methods. Low non-specific adsorption with improved stability for long column lifetime.

Exceptional resolution: Exhibits competitive performance to 3µm SEC products currently available on the market. For both HMW and LMW species, resolution is significantly improved.

Designed for antibody sizing separations: Developed on a 3µm, 250Å pore size particle useful for separating aggregates from monomer, as well as providing increased resolution for lower molecular weight fragments.

Read more about YMC-SEC MAB at:

Also contact:; call 888-341-8380.

About YMC America, Inc.
Established in 1980, YMC America, Inc. is worldwide full-service liquid chromatography company, which offers sales, technical product support, service, application assistance, purification services, contract synthesis and method development.

All YMC products are available worldwide through YMC's network of subsidiaries. This worldwide presence as a full-range chromatography supplier ensures that all YMC products are fully available and fully supported both locally and globally.


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