Manufacturing News / YMC America, Inc.

YMC America, Inc. Unveils New Analytical Chromatography Column: YMC-SEC MAB

Via: ReleaseWire

Updated 7:00 AM CDT, Mon, October 08,2018

Allentown, PA -- (SBWIRE) -- 10/08/2018 -- YMC America, Inc. is pleased to announce the release of their newest size exclusion chromatography column, YMC-SEC MAB. This silica-based SEC column uses a 3µm, 250Å dihydroxypropyl stationary phase which is bonded to a silica gel base, and is specifically designed to be used for antibody separations.

Utilizing a 250Å pore size, this material is well-suited for separating aggregates from monomer, but is also extremely effective at resolving lower molecular weight fragments. Offering high resolution and excellent peak shape over a broad range of molecular weight (10kDa to 700kDa), this material has been shown to work well for both characterization and quality control of antibody drugs. Additionally, YMC-SEC MAB provides excellent lot-to-lot reproducibility, making it an excellent choice for quality control methods.

This new SEC material exhibits low non-specific adsorption and has the ability to significantly improve accuracy on sizing analyses of monoclonal antibodies and other large proteins, including Antibody-Drug Conjugates (ADCs). When running sizing separations of ADCs, it is recommended to add organic solvent (typically ~15%) to the mobile phase in order to suppress any hydrophobic interactions from the higher drug-to-antibody (DAR) species and obtain optimal results.

Interested parties can view the full product specifications here.

Anyone looking to buy analytical columns, such as the new YMC-SEC MAB, or buy silica columns and other chromatography products, can visit YMC America, Inc.'s website at or call 888-341-8380 for additional information.

About YMC America, Inc.
YMC America, Inc. is a wholly-owned subsidiary of YMC Co. Ltd. (established in 1980). YMC America, Inc. sells and supports YMC liquid chromatography products and offers application assistance, purification services, and method development.

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