Manufacturing News / YMC America, Inc.

YMC America, Inc.'s HPLC Columns Help in Nucleic Acid Therapeutics Testing

Via: ReleaseWire

Updated 7:00 AM CDT, Wed, August 15,2018

Allentown, PA -- (SBWIRE) -- 08/15/2018 -- YMC America, Inc. offers a wide range of ultra high-performance liquid chromatography (UHPLC) and high-performance liquid chromatography (HPLC) columns. YMC America, Inc.'s customers can buy HPLC columns as well as other LC column technologies on YMC America, Inc.'s website. These products include but are not limited to reversed phase columns, normal phase HPLC columns, chiral columns, SFC columns, and HILIC columns.

In a publication completed by YMC Co. Ltd., their BioPro ion-exchange columns were found to be instrumental in studying nucleic acid therapeutics. Therapeutics such as antisense and siRNA are anticipated to be important next-generation drugs in the growing pharmaceutical industry. See more here: Optimization of Oligonucleotide Separations on IEX Chromatography

In this application note, different parameters were evaluated for optimizing oligonucleotide ion-exchange chromatography methods. For example, to help reduce carry-over, the study suggests increasing the initial concentration of salt, in this case NaCl. To help improve peak tailing, they investigated optimizing the mobile phase buffer as well as changing the counter ion. Overall, this work found that developing a separation with low carry-over and improved peak tailing of oligonucleotides can be achieved through the optimization of buffer concentration as well as choosing the correct counter ion when using YMC BioPro IEX QF anion exchange columns for the separation.

HPLC Columns from YMC America, Inc. can be used for a wide range of analytes and offer high-quality separation results. Customers who want to buy LC columns, as well as any of the other columns, components, and separation materials provided by YMC America, Inc., can do so by visiting their website at https://www.ymcamerica.com/. Those in need of technical support can call 888-341-8380, and those who are interested in completing a sale over fax can do so by sending orders to 610-266-8652.

About YMC America, Inc.
YMC America, Inc. is a wholly-owned subsidiary of YMC Co. Ltd. (established in 1980). YMC America, Inc. sells and supports YMC liquid chromatography products and offers application assistance, purification services, and method development.

For more information about this global leader, visitors can browse https://www.ymcamerica.com/.

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Nachum Balofsky
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